†These authors contributed equally.
Academic Editor: Graham Pawelec
Background: p62 is a multi-domain protein and participates in a variety
of cellular biological activities. p62 is also related to tumor malignancy.
However, the underlying molecular mechanism of p62 regulating the progression of
hepatocellular carcinoma (HCC) remains unclear. Methods: The expression
levels of p62 in HCC tissues and adjacent non-tumor tissues were confirmed using
the TCGA dataset and immunohistochemistry. Stable p62-overexpressing HepG2 cells
and p62-knockdown MHCC97H cells were established with lentiviral vectors. Cell
proliferation, migration, and invasion assays were carried out to investigate the
role of p62 in HCC cells and HCC-derived exosomes. The relationship between p62
and