Background: World Health Organization (WHO) grade 4 adult-type diffuse
glioma is the most malignant primary tumor of the brain. Nucleolar protein 14
(NOP14) is recognized to contribute significantly to the assembly of
small ribosomal subunits. However, the specific involvement of NOP14 in diverse
cancers remains poorly understood, particularly its role in adult-type diffuse
glioma, which has yet to be elucidated. Methods: A total of 20
adult-type diffuse glioma samples with varying WHO stages were collected. The
protein level of NOP14 was detected using immunohistochemistry. Additionally,
NOP14 expression in LN229 and U251 cell lines and collected clinical tissue
samples was quantified using the Western blot technique. Furthermore, the
correlation between NOP14 and clinicopathological features, survival
rates, matrix and immune scores, and immune components was investigated using
data from the Cancer Gene Atlas database. Results: NOP14
exhibited high expression in adult-type diffuse glioma patients, with the highest
expression observed in the LN229 cell line. Moreover, elevated NOP14
expression was significantly correlated with poorer overall survival and
demonstrated an association with unfavorable pathological features in a cohort of
703 glioblastoma (GBM) patients. Evidence of a connection between NOP14
and the tumor microenvironment was presented. Elevated NOP14 was linked
to the infiltration of CD8
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Open Access
Original Research
NOP14 as a Potential Predictor of Adult-Type Diffuse Glioma Prognosis and Immunotherapy, is Related to Cell Migration, Proliferation, and CD8+T Cell Infiltration
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1
Department of Neurosurgery, 3201 Hospital of Xi'an Jiaotong University Health Science Center, 723000 Hanzhong, Shaanxi, China
2
Department of Pathology, 3201 Hospital of Xi'an Jiaotong University Health Science Center, 723000 Hanzhong, Shaanxi, China
*Correspondence: baozhijun3201@163.com (Zhi-jun Bao)
Front. Biosci. (Landmark Ed) 2024, 29(3), 104;
https://doi.org/10.31083/j.fbl2903104
Submitted: 22 November 2023 | Revised: 3 January 2024 | Accepted: 24 January 2024 | Published: 15 March 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
NOP14
glioblastoma
tumor-infiltration
prognosis
CD8+T cell
Funding
TYYLKYJJ-2022-014/General Medical Research Fund
Figures
Fig. 1.