- Academic Editor
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Background: The prevalence of laryngeal squamous cell carcinoma (LSCC)
is increasing, and it poses a significant threat to human health; therefore,
identifying specific targets for LSCC remains crucial. Methods:
Bioinformatics analysis was used to compare the different expression genes
expressed in LSCC. Immunohistochemical assay and western blotting were used to
analysis protein expression. Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide)((4,5 Dimethyl thiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide)4,5 Dimethyl thiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) and 5-ethynyl 2
CRNN is an important hubgene that connects DEGs in LSCC.
CRNN is downregulated in LSCC and associated with poor patient survival.
CRNN negatively regulated cell viability, cell cycle, cell migration and cell invasion.
In nude mice, CRNN also negatively regulated tumorigenesis.