Background: The endogenous
metabolism of polyunsaturated fatty acids is regulated by the fatty acid
desaturase (FADS) gene cluster and is strongly associated with diseases such as
atherosclerosis, dyslipidemia, and type 2 diabetes. However, the association
between FADS and atherosclerosis remains a subject of debate. Methods:
In this study, we specifically investigated the physiological role of
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Open Access
Original Research
Targeted Knockdown of Hepatic Δ-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE-/- Mice
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1
Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China
2
Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China
*Correspondence: sdws188@163.com (Sheng Wang)
Front. Biosci. (Landmark Ed) 2024, 29(4), 131;
https://doi.org/10.31083/j.fbl2904131
Submitted: 24 September 2023 | Revised: 15 February 2024 | Accepted: 6 March 2024 | Published: 29 March 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
Δ-5 fatty acid desaturase
atherosclerosis
antisense oligonucleotides
angiopoietin-like 4
Funding
2022409422/Director’s Fund of Beijing Anzhen Hospital
Figures
Fig. 1.