IMR Press / CEOG / Volume 41 / Issue 2 / DOI: 10.12891/ceog17642014

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Case Report
Pregnancy management in Behcet’s disease treated with uninterrupted infliximab. Report of a case with fetal growth restriction and mini-review of the literature
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1 Department of Gynaecology and Obstetrics, S. Leonardo Hospital, Castellammare di Stabia, Naples
2 Department of Woman, Child and of General and Specialized Surgery, Second University of Studies of Naples, Naples (Italy)
Clin. Exp. Obstet. Gynecol. 2014, 41(2), 205–207; https://doi.org/10.12891/ceog17642014
Published: 10 April 2014
Abstract

Background: The mutual impact of Behcet’s disease (BD) and pregnancy is variable and still unclear. Among the safe drugs administered, the newer infliximab (IFX) was rarely experienced in pregnancy, particularly in the third trimester. Case: The authors report a pregnancy with fetal growth restriction at 36 weeks in a 31-year-old primigravida with symptomatic BD, treated with uninterrupted monthly IFX and daily enoxaparin. The patient was induced at 38 weeks and had an uneventful vaginal delivery of a healthy baby. The postpartum period and following six months were uneventful for mother in terms of BD exacerbation, and newborn in terms of potential risks of neonatal BD and/or infections due to late immunosuppressive IFX administration. Conclusion: Because of the inconstant mutual impact, BD pregnancies should be precautionary considered at “potential high-risk” and need a careful and close monitoring by a multidisciplinary team with specific expertise.
Keywords
Behcet’s disease
Vasculitis
Infliximab
Pregnancy
Obstetric outcome
Fetal growth restriction
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