IMR Press / CEOG / Volume 41 / Issue 5 / DOI: 10.12891/ceog17382014

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Maternal serum pregnancy-associated plasma protein-A levels in hyperemesis gravidarum: a prospective case control study
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1 Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Department of Perinatology, Ankara (Turkey)
Clin. Exp. Obstet. Gynecol. 2014, 41(5), 534–536; https://doi.org/10.12891/ceog17382014
Published: 10 October 2014
Abstract

Purpose: To investigate if maternal serum pregnancy-associated plasma protein-A levels are affected in hyperemesis gravidarum (HG). Materials and Methods: A prospective case control study was conducted in 169 HG cases who had one or more antepartum hospitilization for HG. The control pregnancies were 132 and were selected randomly among all women who had first trimester prenatal screening in antenatal outpatient clinic between 2011 and 2012. Results: Maternal serum pregnancy-associated plasma protein-A levels were significantly higher in hyperemesis gravidarum group compared with control group (p = 0.002 p < 0.05 95% CI). Power analysis of independent sample t-test, two-sided, for pregnancy-associated plasma protein-A was 0.88. Maternal serum free β-human chorionic gonadotropin values were not different between two groups (p > 0.05). Conclusion: Increased pregnancy-associated plasma protein- A levels associated with HG, even after excluding potential cofounders.
Keywords
Pregnancy-associated plasma protein-A (PAPP-A)
Hyperemesis gravidarum
Human chorionic gonadotropin (hCG)
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