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Original Research
Expression of heparanase in the spontaneously aborted human chorionic villus
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1
Institute of Immunology, Shanxi Datong University School of Medicine, Datong, China
2
Department of Obstetrics and Gynecology, Shanxi Datong University School of Medicine, Datong, China
Clin. Exp. Obstet. Gynecol. 2018, 45(2), 174–177;
https://doi.org/10.12891/ceog3796.2018
Published: 10 April 2018
Abstract
Objective: Heparan sulfate proteoglycans (HSPG) are main components of remodeling the extracellular matrix (ECM). Heparanase (HPSE) can cleave the HSPG and alter the structural integrity of the ECM. The present research was to investigate the role of HPSE in recurrent spontaneous abortion (RSA). Study Design: Reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical methods were used to determine the expression of heparanase (HPSE) in the villus of the human normal pregnancy and RSA. Results: The expressions of HPSE mRNA and protein in the normal group were significantly greater in comparison with those in the spontaneous abortion group (p < 0.05). Conclusion: The HPSE participates in the procedure of normal pregnancy, and the lower expression of HPSE may lead to the spontaneous abortion.
Keywords
Recurrent spontaneous abortion
HPSE
Reverse transcription-PCR
Immunohistochemical methods