Objective: The relationship between thyroid autoantibodies (TA) and early missed abortion remains unclear, and therefore, their relationship was investigated in this research. Study Design: One hundred cases of missed abortion women were selected as test group, and 100 early pregnant women were enrolled as control group. Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were determined by electrochemiluminescence, the positive rates and levels of TPOAb and TgAb were compared, and their relationship with early missed abortion was analyzed by logistic regression analysis. Results: The results indicated that the positive rates of TPOAb and TgAb in the test group was much higher than the control group (p < 0.05). The serum level of TPOAb in early missed abortion females was also higher than the control group (0. 93 ± 0. 65 vs. 0. 72 ± 0. 28, p < 0.01), while no significant differences for TgAb between the test group and normal controls (1. 34 ± 0. 46 vs. 1. 31 ± 0. 26, p > 0.05). According to the logistic analysis, the authors found that the positive rates of TPOAb in the test group was 4.129 times higher than that in the control group (p = 0.004), and might be an independent risk factor for early missed abortion. Conclusion: In summary, the authors inferred that TA positive was related to early missed abortion, and TPOAb positive was an independent dangerous factor.