IMR Press / CEOG / Volume 46 / Issue 1 / DOI: 10.12891/ceog4117.2019
Open Access Original Research
The relationship between vitamin D and IVF: a systematic review and meta-analysis
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1 Department of Obstetrics and Gynecology, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China
Clin. Exp. Obstet. Gynecol. 2019 , 46(1), 12–15; https://doi.org/10.12891/ceog4117.2019
Published: 10 February 2019
Abstract

Vitamin D deficiency does not influence IVF outcomes, but is related to lower pregnancy and it is important to provide more reliable evidence on vitamin D in IVF due o the published studies which are strongly contradictory. Objectives: To explore the effect of vitamin D in IVF with a focus on the outcome of clinical pregnancy in published studies. Materials and Methods: The authors used PubMed, EMBASE, Web of knowledge (SCI), and Cochrane Library Methods to explore all studies that evaluate vitamin D levels and IVF outcomes until 2016. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated for analyses. Result: The authors first classified two groups to investigate the influence of vitamin D in IVF. There was no significant difference with deficient vitamin D and IVF outcome (RR 0.88, 95% CI 0.74-1.04; I2 63%, seven trials; 1,865 participants). In addition, vitamin D deficiency also di not show a significant difference in IVF outcome (RR 0.91, 95 % CI 0.77-1.18, RR 0.91, 95% CI, 0.77-1.18; I2, 72 trials, 1,172 participants). Conclusion: There is no significance between vitamin D status (deficiency or replete) and IVF outcomes, but it was also found that vitamin D deficiency was inclined to lower IVF pregnancy outcome.

Keywords
Vitamin D deficient
vitamin D replete
IVF
Clinical pregnancy rate
Endometrium
Infertility
Embryo transfer
Cut-off values
Figures
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