IMR Press / CEOG / Volume 46 / Issue 5 / DOI: 10.12891/ceog4608.2019
Open Access Original Research
Pregnancy success rate at recurrent implantation failure patients after hysteroscopic endometrial injury: preliminary study
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1 Acibadem Mehmet Ali Aydinlar University Atakent Hospital, Obstetrics and Gynecology Clinic, Infertility Section, Istanbul, Turkey
2 Acibadem Mehmet Ali Aydinlar University School of Medicine, Department of Obstetrics&Gynecology, Istanbul, Turkey
Clin. Exp. Obstet. Gynecol. 2019 , 46(5), 709–712;
Published: 10 October 2019

Purpose of Investigation: To assess better implantation and pregnancy rates following endometrial injury in the presence of previous implantation failure, through a retrospective study in a tertiary University Clinic. The aim of this study is to assess improved embryo implantation after hysteroscopic fundal endometrial injury in repeated implantation failure in patients. Materials and Methods: Twenty-nine women who had recurrent implantation failure participated in the study. They had three or more implantation failures with good quality embryo. Anti-Mullerian hormone (AMH) levels, age, antral follicle count, body mass index, and FSH levels were collected. Frozen/thawed embryos (FTE) were transferred in all subjects. Before embryo transfer the authors performed hysteroscopic endometrial injury by micro cold knife. Results: Median age was 38.62 ± 2.47 years in the study. AMH levels changed between 0.35 and 3.8 ng/ml. The pregnancy rate following hysteroscopy: 17 (58,6%) were pregnant and 12 of 29 subjects did not become pregnant. The women who became pregnant following hysteroscopy were younger and had a higher antral follicle count than the non-pregnant women (p = 0.030 and p = 0.0017 respectively; p < 0.05). Conclusion: The endometrial injury before frozen-thawed embryo transfer had a positive effect on patients who had previous recurrent implantation failure.

Recurrent implantation failure
In-vitro fertilization
Local endometrial injury
Clinical pregnancy rate
Figure 1.
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