IMR Press / CEOG / Volume 46 / Issue 5 / DOI: 10.12891/ceog4939.2019
Open Access Case Report
Pregnancy outcome following intentional ampicillin and pyridium overdose during the second trimester: a case report
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1 Department of Pharmacology and Toxicology, Health Sciences University, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey
2 Department of Pharmacology, Izmir Kâtip Celebi University School of Medicine, Izmir, Turkey
3 TERAFAR-Izmir Kâtip Celebi University Teratology Information, Training and Research Center, Izmir, Turkey
4 Department of Obstetrics and Gynaecology, Izmir Kâtip Celebi University School of Medicine, Ataturk Research and Training Hospital, Izmir, Turkey
Clin. Exp. Obstet. Gynecol. 2019 , 46(5), 842–843; https://doi.org/10.12891/ceog4939.2019
Published: 10 October 2019
Abstract

There are no data focusing on the safety of overdose of ampicillin and pyridium during pregnancy. This study aims to report the outcome of a pregnant woman with an acute overdose of oral ampicillin+pyridium in the 14th week of pregnancy. A 27-year-old woman was referred to Teratology Information Service with a suicide history of ingesting 28 ampicillin+pyridium (500+50 mg) tablets. A structured, evidence-based counseling regarding her exposure to overdosing was provided, and she decided to continue her pregnancy. She gave birth to a baby in the 38th gestational week with fetal growth restriction (FGR), with no major congenital malformations and/or deformations. The follow-up of the infant in the 14th month of her life revealed normal physical and neurodevelopmental findings. Because the mother had no major risk factors and exposure of experimental animals to this overdosage have yielded comparable results, and the FGR in this case may be attributed to medication exposure.

Keywords
Ampicillin
Pyridium
Teratology Information Service
Pregnancy
Congenital malformations
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