IMR Press / CEOG / Volume 47 / Issue 3 / DOI: 10.31083/j.ceog.2020.03.5222
Open Access Case Report
Acute fatty liver during pregnancy and gestational diabetes insipidus: a case report
H.J. Wang1,†T.H. Chou2,†Y.C. Lee1H.K. Au1,3,4,*
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1 Department of Obstetrics and Gynecology, Taipei Medical University Hospital, 11031 Taipei, Taiwan
2 Department of Internal Medicine, Taipei Medical University Hospital, 11031 Taipei, Taiwan
3 Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, 11031 Taipei, Taiwan
4 Center for Reproductive Medicine, Taipei Medical University Hospital, 11031 Taipei, Taiwan
*Correspondence: hengkienau@gmail.com (HENG-KIEN AU)
Contributed equally.
Clin. Exp. Obstet. Gynecol. 2020, 47(3), 438–441; https://doi.org/10.31083/j.ceog.2020.03.5222
Submitted: 6 August 2019 | Accepted: 16 October 2019 | Published: 15 June 2020
Copyright: © 2020 Wang et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/.
Abstract

Acute fatty liver during pregnancy (AFLP) is an emergency and potentially fatal condition occurring during the peripartum period. It is characterized by fatty microvascular infiltration of hepatocytes and has an incidence rate of approximately one in 7,000 to one in 20,000 pregnancies. It may induce profound liver failure and can be accompanied by renal failure, polydipsia/polyuria, disseminated intravascular coagulation, hypoglycemia, and encephalopathy. Emergency delivery at the appropriate time is crucial to control the development of AFLP. Gestational diabetes insipidus (GDI) is another rare disorder characterized by polyuria, polydipsia, and dehydration. It has an incidence rate of 2-4 cases/100,000 pregnancies and develops during the third trimester. Here the authors present the case of a patient with AFLP and transient GDI complicated with non-reassuring fetal status. The conditions were resolved after delivery and multidisciplinary intensive care.

Keywords
Acute fatty liver during pregnancy
Deamino arginine vasopressin
Fetal distress
Gestational diabetes insipidus
Pregnancy complications
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