IMR Press / CEOG / Volume 47 / Issue 4 / DOI: 10.31083/j.ceog.2020.04.5243
Open Access Original Research
Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta
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1 Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. China
2 Second affiliated hospital of Fujian medical university, Quanzhou, Fujian, 362001, P.R. China

Contributed equally.

Clin. Exp. Obstet. Gynecol. 2020 , 47(4), 565–570; https://doi.org/10.31083/j.ceog.2020.04.5243
Submitted: 21 April 2019 | Accepted: 22 July 2019 | Published: 15 August 2020
Abstract

Objective: This study aims to explore the role of hypoxia inducible factor-1α (HIF-1α) in morbidly adherent placenta (MAP). Materials and Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa, and 30 normal pregnant women as controls participated in the present study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of HIF-1α in the placenta. Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the HIF-1α protein levels in the placenta. Results: The mean expression of placental HIF-1α in the placenta increta and placenta previa groups was significantly higher than that in the normal placenta. The level of placental HIF-1α in the placenta increta was significantly higher than that in the placenta previa (p < 0.05). The level of placental HIF-1α had no obvious correlation with the accreta site and umbilical cord insertion. Conclusion: The morbidly of adherent placenta is closely correlated to adverse pregnancy outcomes during the perinatal period. Placental HIF-1α is associated with morbidly adherent placenta.

Keywords
HIF-1α
Placenta increta
Placenta previa
Pathogenesis
Morbidly adherent placenta
Figures
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