Objective: This study aims to determine the protective effects of
apocynin, a NADPH oxidase inhibitor, and melatonin, an endogenous anti-oxidant,
in an animal model of ovarian ischemia/reperfusion (I/R) injury. Materials/Methods: Thirty-five female rats were randomly divided into
five groups, namely group I (sham), group II (I/R), group III (I/R
Announcements
Open Access
Original Research
Protective effects of apocynin and melatonin on ovarian ischemia/reperfusion injury in rats
Çiğdem Kunt İşgüder1,*, Murat Uysal2, Özlem Koşar Can3, Mine Kanat Pektaş4, Akgül Arici5, Velid Unsal6
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1
Department of Obstetrics and Gynecology, Faculty of Medicine Istanbul, Istanbul University, 34452 Istanbul, Turkey
2
Department of Anatomy, Faculty of Medicine, Gaziosmanpasa University, 60250 Tokat, Turkey
3
Department of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, 20160 Denizli, Turkey
4
Department of Obstetrics and Gynecology, Faculty of Medicine, Afyonkarahisar University of Health Sciences, 03200 Afyonkarahisar, Turkey
5
Department of Pathology, Faculty of Medicine, Gaziosmanpasa University, 60250 Tokat, Turkey
6
Faculty of Health Sciences and Central Research Laboratory, Mardin Artuklu University, 47200 Mardin, Turkey
*Correspondence: cidos_55@hotmail.com (Çiğdem Kunt İşgüder)
Clin. Exp. Obstet. Gynecol. 2021, 48(1), 98–104;
https://doi.org/10.31083/j.ceog.2021.01.5488
Submitted: 13 January 2020 | Revised: 25 July 2020 | Accepted: 31 July 2020 | Published: 15 February 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by-nc/4.0/).
Abstract
Keywords
Apocynin
Ischemia
Melatonin
Ovary
Reperfusion injury
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