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Maternal serum pregnancy-associated plasma protein-A concentration at 11–14 weeks of gestation of women with common congenital anatomic uterine abnormalities
Sotirios Sotiriou1,*, Maria Satra2, Dimitra N. Vamvakopoulou3, Chrisostomos Sofoudis4, Aikaterini Simou5, Thomas Kilindris6, Andreas Sidiropoulos2, Konstantinos V. Kakavas7, Antonis Garas5, Hara Skentou1, Nikos C. Vamvakopoulos2, Alexandros Daponte5
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1
Laboratory of Histology and Embryology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
2
Laboratory of Biology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
3
Department of Pediatrics and Neonatology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
4
Deptartment of Obstetrics and Gynecology, Konstandopoulio General Hospital, GR-11472 Athens, Greece
5
Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
6
Laboratory of Medical Informatics, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
7
Laboratory of Environmental quality and human health, Department of Environment, University of Thessaly, GR-41500 Larissa, Greece
*Correspondence: sotiriousoti@yahoo.gr (Sotirios Sotiriou)
Clin. Exp. Obstet. Gynecol. 2021, 48(2), 343–346;
https://doi.org/10.31083/j.ceog.2021.02.2319
Submitted: 8 October 2020 | Revised: 23 November 2020 | Accepted: 25 November 2020 | Published: 15 April 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Objectives: To evaluate maternal serum pregnancy-associated plasma
protein-A (PAPP-A) levels at 11–14 weeks of gestation in women with common
congenital anatomic uterine abnormalities (AUAs).
Methods: First trimester screening markers were compared between 12
AUA pregnancies and 60 age matched controls.
Results: PAPP-A level and birth weight were significantly lower in
AUA compared to control pregnancies (P
Keywords
Pregnancy-associated plasma protein A
PAPP-A
Congenital anatomic uterine abnormalities
AUA
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