IMR Press / EJGO / Volume 38 / Issue 3 / DOI: 10.12892/ejgo3449.2017
Open Access Original Research
Multiple primary cancers in BRCA1/2 carriers – A review of literature and our observations
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1 Department of Perinatology and Gynecology, Karol Marcinkowski University of Medical Science, Poznań, Poland
2 Department of Oncology, Karol Marcinkowski University of Medical Science, Poznań, Poland
Eur. J. Gynaecol. Oncol. 2017 , 38(3), 361–363; https://doi.org/10.12892/ejgo3449.2017
Published: 10 June 2017
Abstract

An increasing number of patients with diagnosed synchronous or metachronous neoplasms that are gene as well as non-gene dependent which are associated with the development of new oncological treatment, and environmental factors, prompted the authors of this study to conduct an analysis in a narrow group of patients with multiple cancers and simultaneous BRCA1 mutations (confirmed by genetic analysis). BRCA1 mutation, as well as multiple cancers were found in seven patients treated between 2007 and 2013. The patients diagnosed with a second cancer shared a uniquely common trait – a 5382insC mutation. The study describes four patients that did not carry a BRCA1/2 mutation, yet were diagnosed with multiple cancers. A brief review of literature was performed concerning multiple cancers in women.
Keywords
Synchronous
Metachronous
BRCA1/2 mutation
Multiple cancers
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