IMR Press / EJGO / Volume 38 / Issue 5 / DOI: 10.12892/ejgo3662.2017
Open Access Original Research
Association of myeloperoxidase -463G>A polymorphism with cervical cancer in Chinese Han women
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1 Department of Obstetrics and Gynecology, Fuzhou General Hospital of Nanjing Military Command/Dongfang Hospital, Xiamen University, Fuzhou, China
2 Institute of Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command/Dongfang Hospital, Xiamen University, Fuzhou, China
Eur. J. Gynaecol. Oncol. 2017 , 38(5), 756–759; https://doi.org/10.12892/ejgo3662.2017
Published: 10 October 2017
Abstract

Objective: Myeloperoxidase (MPO) is an endogenous oxidant in neutrophilic and monocytic cytoplasmic granules. Several epidemiological studies indicate that MPO genetic polymorphisms are associated with cancer risk. Thus the present assessed an association between the MPO -463G>A polymorphism and cervical cancer risk in Chinese Han women. Materials and Methods: A hospital-based case-control study included 276 Chinese Han patients with cervical cancer and 284 age-, and ethnic-matched controls. The MPO -463G>A polymorphism was analyzed with PCR-restriction fragment length polymorphism (RFLP). Associations between the MPO polymorphism and cervical cancer risk were confirmed with χ2 tests. Results: No significant differences occurred among genotype distributions of the MPO -463G>A polymorphism between patients and controls. In a subgroup analysis of cervical cancer patients, there was no association between the MPO polymorphism and cervical cancer histological types or grades or tumor stage. Conclusions: The MPO -463G>A polymorphism is not associated with a risk of cervical cancer in Chinese Han women.
Keywords
Myeloperoxidase
Polymorphism
Cervical cancer
Chinese
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