IMR Press / EJGO / Volume 39 / Issue 3 / DOI: 10.12892/ejgo3962.2018
Open Access Original Research
Significance and expression of c-erBb-2, p53, and caspase-3 in breast cancer tissue in different age groups
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1 Department of Breast Surgery, Tangshan Maternity and Child Health Care Hospital, Tangshan, China
2 Department of Pathology, Tangshan Maternity and Child Health Care Hospital, Tangshan, China
Eur. J. Gynaecol. Oncol. 2018 , 39(3), 430–432; https://doi.org/10.12892/ejgo3962.2018
Published: 10 June 2018
Abstract

Objective: The aim of this study was to explore the expression of c-erBb-2, p53, and caspase-3 in breast cancer tissue in different age groups. Materials and Methods: One hundred seventy-two patients with breast cancer were divided into two groups by age (≤ 35 and ≥ 40 years). Immunohistochemical analysis was performed to detect the expression of c-erBb-2, p53, and caspase-3 in the tumor tissue from the patients. The authors compared the expression levels between the two groups. Results: In 90 young women with breast cancer, the positive expression rate of c-erBb-2, p53, and caspase-3 was 41.1% (37/90), 67.8% (61/90), and 35.6% (32/90), respectively, and it was 23.2% (19/82), 40.8% (39/82), and 57.3% (47/82), respectively, in the older patients. In the young group, the expression of caspase-3 was significantly lower (p < 0.05) and the expression of c-erbB-2 and p53 were significantly higher (p < 0.01). Conclusion: The biological behavior of breast cancer and apoptosis is associated with the expression of p53 and c-erbB-2; thus, more attention should be paid to the expression of cell apoptotic factors when treating and assessing the prognosis of patients with breast cancer.
Keywords
Breast cancer
Apoptotic factor
Immunohistochemical assay
Prognosis
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