IMR Press / EJGO / Volume 40 / Issue 2 / DOI: 10.12892/ejgo4517.2019
Open Access Case Report
Vaginal clear cell adenocarcinoma in a young woman with a Müllerian duct anomaly and no history of in utero diethylstilbestrol exposure: a fertility-sparing approach
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1 Department of Obstetrics and Gynecology, "Magna Graecia" University, Catanzaro, Italy
Eur. J. Gynaecol. Oncol. 2019 , 40(2), 334–336; https://doi.org/10.12892/ejgo4517.2019
Published: 10 April 2019
Abstract

Since most cases of primary vaginal clear cell adenocarcinoma (PVCCA) occur during the reproductive years, it is necessary to evaluate the safety and efficacy of potential fertility-sparing approaches. Herein, the authors report a case of a young woman with a Müllerian duct anomaly and a primary diagnosis of PVCCA without a history of in utero diethylstilbestrol (DES) exposure. She was treated with a fertility-sparing approach involving organ-preserving surgery and oocyte cryopreservation in conjunction with adjuvant pelvic radiotherapy. To date, disease recurrence has not been documented.

Keywords
Primary vaginal clear cell adenocarcinoma (PVCCA)
Müllerian duct anomaly
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