IMR Press / EJGO / Volume 40 / Issue 2 / DOI: 10.12892/ejgo4535.2019
Open Access Original Research
The association between p16INK4a and prognosis in endometrial carcinoma: a meta-analysis
H. Cao1,†S. Yang2,†S. Xie3M. Xi1,*
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1 Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
2 Laboratory of Lung Development and Disease, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
3 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu City, China

Contributed equally.

Eur. J. Gynaecol. Oncol. 2019 , 40(2), 311–317; https://doi.org/10.12892/ejgo4535.2019
Published: 10 April 2019
Abstract

Purpose of Investigation: P16INK4a has been suggested to be involved in the prognosis of various human malignancies. The purpose of this study was to analyze the prognostic impact of overexpressed P16INK4a in endometrial carcinoma. Materials and Methods: The PubMed, Embase, and Web of Science were searched for relevant publications in English language and the China National Knowledge Infrastructure was searched for studies in Chinese language. The pooled odds ratios (ORs) or risk ratios (RRs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of association. Results: Overall, 26 studies with 1,628 patients were included. The P16 INK4a overexpression was found to correlate significantly with the lower histological grade (OR = 0.44, 95%CI: 0.25- 0.78, P = 0.005, random effect), negative lymph node metastasis (OR = 0.39, 95%CI: 0.20-0.76, P = 0.005, fixed effect) and ≤1/2 myometrial infiltration (OR = 0.63, 95% CI: 0.40-1.00, P = 0.05, fixed effect). However, no significant association was found between P16 INK4a and FIGO (International Federation of Gynecology and Obstetrics) stage (OR= 0.80, 95% CI: 0.46-1.37, P = 0.409, random effect), histological type (OR= 1.21, 95% CI: 0.40-3.61, P = 0.735, random effect) or overall survival (RR = 0.74, 95% CI: 0.20-2.72, P = 0.653, random effect). Subgroup analysis indicated that the associations might differ based on geographical location, sample size, publication year, cut-off value, and study quality. Conclusion: The P16 INK4a might be a potential biomarker for better prognosis of endometrial carcinoma.

Keywords
p16INK4a
Endometrial carcinoma
Immunohistochemistry
Prognosis
Figures
Figure 1.
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