IMR Press / EJGO / Volume 40 / Issue 5 / DOI: 10.12892/ejgo4919.2019
Open Access Original Research
Umbilical cord-derived mesenchymal stem cells efficiently induced apoptosis of endometrial carcinoma cells
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1 Department of Gynecology and Obstetrics, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shanxi, China
2 Department of Otolaryngological, Tangdu, The Fourth Military Medical University, Xi'an, Shanxi, China

Contributed equally

Eur. J. Gynaecol. Oncol. 2019 , 40(5), 839–845; https://doi.org/10.12892/ejgo4919.2019
Published: 10 October 2019
Abstract

Purpose of Investigation: To investigate the mechanism of apoptosis of AN3CN cells, an endometrial cancer (EC) cell line, induced by human umbilical cord mesenchymal stem cells (hUCMSCs). Materials and Methods: UC-MSCs and AN3CN cells were co-cultured and CCK-8 cell proliferation assay was used to assess cell proliferation. Results: By co-culture with hUCMSCs, the proliferation of AN3CN cells was significantly inhibited (p < 0.001) and the cell cycle of AN3CN cells was arrested in the G2 phase. Furthermore, this study indicated that changes in the PI3K/Erk/JNK/Bcl-2/DR5 signal pathway-related genes promoted apoptosis of AN3CN cells. Conclusion: This finding not only helps us understand the molecular mechanism of hUCMSCs inhibiting tumor growth and promoting apoptosis, but also provides us a strong rationale to further investigate hUCMSCs as a potential treatment of EC.

Keywords
Apoptosis
AN3CN cells
Human umbilical cord mesenchymal stem cells
PI3K/Erk/JNK/Bcl-2/DR5
Figures
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