IMR Press / EJGO / Volume 41 / Issue 2 / DOI: 10.31083/j.ejgo.2020.02.4916
Open Access Original Research
Expression of HIWI in endometrial carcinoma tissues and its clinical significance
H. Wang1,†Y. Peng5,†Y. Liu6,†X. Li6A. Gu2H. He3M. Fen4D. Mao7L. Guo1,*
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1 Department of Gynecologic Oncology, Cancer Hospital Affiliated to Harbin Medical University, Harbin, China
2 Department of Radiotherapy Oncology, Cancer Hospital Affiliated to Harbin Medical University, Harbin, China
3 Department of Head and Neck Surgery for Thyroid, Cancer Hospital Affiliated to Harbin Medical University, Harbin, China
4 Department of Pathology, Cancer Hospital Affiliated to Harbin Medical University, Harbin, China
5 Disease Prevention Center, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
6 Department of Sports Science and Health, Harbin Sport University, Harbin, China
7 Department of Gynaecology, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China

Contributed equally.

Eur. J. Gynaecol. Oncol. 2020 , 41(2), 256–259; https://doi.org/10.31083/j.ejgo.2020.02.4916
Published: 15 April 2020
Abstract

Objective: This study aims to investigate the expression of the HIWI gene and explore its relationship with endometrial carcinoma. Materials and Methods: This study included 72 endometrial carcinoma (EC) cases. The study also analyzed 68 cases of endometrial benign disease and 78 cases of normal endometrium. Immunohistochemistry and western blot were used to detect the expression of HIWI in different tissues. Results: The expression level of HIWI was significantly higher in endometrial carcinoma than in benign endometrium and normal endometrium (P < 0.05). In addition, HIWI expression was significantly correlated with tumor myometrial invasion depth, cervical invasion, lymph vascular invasion, lymph node metastasis and clinical stage (P < 0.05), but was not correlated with the age or menstrual period of patients (P > 0.05). Conclusion: HIWI is correlated to the occurrence and development of endometrial carcinoma, and may be one of the factors that affect the prognosis of endometrial carcinoma.

Keywords
HIWI
Endometrial carcinoma
Immunohistochemitry
Western blot
Figures
Figure 1.
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