IMR Press / EJGO / Volume 41 / Issue 2 / DOI: 10.31083/j.ejgo.2020.02.5220
Open Access Case Report
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): report of three cases and literature review
Show Less
1 Department of Pathology, Shenzhen People's Hospital, Shenzhen, Guangdong Province, China
2 Department of Pathology, Southern Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
3 Department of Pathology, Fourth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
Eur. J. Gynaecol. Oncol. 2020 , 41(2), 303–307; https://doi.org/10.31083/j.ejgo.2020.02.5220
Published: 15 April 2020
Abstract

Background: Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT), is a rare ovarian tumor with hypercalcaemia mainly affecting young females, but its histogenesis remains largely unknown, which makes it a challenge for effective diagnosis and treatment. This report describes three cases of SCCOHT in young women aging between 23 and 31 years. Material and Methods: All three patients with SCCOHT were subjected to sex hormone and normal blood calcium test, B-ultrasound, and microscopic examination for diagnosis. Expression of low molecular weight Cytokeratin, Vimentin, INI1, WT1, and SMARCA4 were determined by immunohisto-chemistry. Morphological features of cancer cells were observed using electron microscopy, and gene mutation was analyzed by DNA sequencing. Results: All three SCCOHT patients were diagnosed by pathology examination, B-ultrasound, and increased blood calcium level, and underwent surgical resection followed by chemotherapy. Immunohistochemistry showed positive expression of WT-1, CK, INI1, Vimentin, EMA, CD10, and CD56 in tumor tissues of all three cases, but no expression of a-Inhibin, Bcl6, PLAP, Alk, SALL4, SMARCA4, OCT3/4, SF1, Calretinin, MPO, CD20, AFP, CD5, hCG-β, BCL2, ER, and S100. No mutations in FOXL2 gene were detected in these three SCCOHT cases. Two patients died within one year after surgery, and one was lost to follow-up. Conclusion: Three cases of young female SCCOHT patients were reported in this report, featured with poor prognosis even after surgery and chemotherapy.

Keywords
SCCOHT
Small cell carcinoma of the ovary
Hypercalcaemia
INI1
SMARCA4
Figures
Figure 1.
Share
Back to top