IMR Press / EJGO / Volume 41 / Issue 4 / DOI: 10.31083/j.ejgo.2020.04.5189
Open Access Systematic Review
Correlation of MMP2-C1306T (rs243865) and MMP7-181A/G (rs11568818) with cervical cancer: a meta-analysis
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1 Department of Ultrasonic, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, P. R. China
Eur. J. Gynaecol. Oncol. 2020 , 41(4), 508–512; https://doi.org/10.31083/j.ejgo.2020.04.5189
Submitted: 5 February 2018 | Accepted: 20 May 2019 | Published: 15 August 2020
Abstract

Objective: We aimed to determine whether a correlation exists between the polymorphisms of matrix metalloproteinases (MMPs) MMP2-C1306T (rs243865) and MMP7-181A/G (rs11568818) and cervical cancer (CC). Methods: A literature search up to September 28, 2018, in PubMed, the Cochrane Library, and Embase was conducted. Odds ratio (OR) and 95% confidence interval (CI) were used as effect models. The quality, heterogeneity, and publication bias of the included studies were assessed. Results: Five studies with a total of 1,630 participants were included. For the G vs. A and GG vs. AA model of the rs11568818 gene, no significant heterogeneity was found (p < 0.05, I 2 > 50%). No statistical significance was found for all the rs243865 models, indicating no significant association between rs243865 and CC. The meta-analysis of the rs11568818 gene polymorphism revealed a statistical significance for G vs. A (OR = 1.3719; 95% CI, 1.1480-1.6395; P = 0.0005), GG vs. AA (OR = 1.8561; 95% CI, 1.2682-2.7165; P = 0.0015), and GG vs. AA+GA (OR = 1.7448; 95% CI, 1.0104-3.0130; P = 0.0458). No publication bias was found for all the rs11568818 and rs243865 models, which suggested that the present results were reliable. Conclusions: MMP7-181A/G (rs11568818) was associated with CC; however, MMP2-C1306T (rs243865) was not associated with CC.

Keywords
Cervical cancer
Gene polymorphism
Matrix metalloproteinases
Meta-analysis
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