IMR Press / EJGO / Volume 42 / Issue 2 / DOI: 10.31083/j.ejgo.2021.02.2105
Open Access Original Research
8-OHdG repair is associated with platinum sensitivity in high-grade serous ovarian carcinoma
Show Less
1 Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, 210009 Nanjing, Jiangsu, China
2 Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, 210011 Nanjing, Jiangsu, China
3 Department of Chemotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, 210009 Nanjing, Jiangsu, China
4 Nanjing Gaochun People’s Hospital, 211300 Nanjing, Jiangsu, China
5 The Medical College of Yangzhou University, 225009 Yangzhou, Jiangsu, China

These authors contributed equally.

Eur. J. Gynaecol. Oncol. 2021 , 42(2), 254–264; https://doi.org/10.31083/j.ejgo.2021.02.2105
Submitted: 13 April 2020 | Revised: 15 August 2020 | Accepted: 24 August 2020 | Published: 15 April 2021
Abstract

Objectives: This study investigated 8-OHdG repair-related gene polymorphisms, 8-OHdG concentration and their association with the risk and survival of high-grade serous ovarian carcinoma (HG-SOC). Methods: Germline variants in the 8-OHdG repair pathway were assessed in 350 sporadic HG-SOC patients (HG-SOCs) and 700 healthy controls. The 8-OHdG concentration in leukocyte DNA was measured by ELISA. Cox proportional hazard models and log-rank test were used to conduct the survival analysis. Results: The genotype and allele frequencies of OGG1 c.977C > G, MUTYH c.972G > C, and TP53 codon 72 Arg/Pro were different to those of platinum-sensitive recurrent HG-SOCs and refractory/platinum-resistant recurrent sub HG-SOCs (P = 0.04, 0.05, and 0.03, respectively). The average value of 8-OHdG/106 dG was higher in patients with OGG1 c.977G, MUTYH c.972G, or TP53 codon 72 Arg alleles (all P < 0.01). High 8-OHdG concentrations in leukocyte DNA was independently associated with shorter overall survival (OS) (P < 0.01) and progression-free survival (PFS) in HG-SOCs. Conclusion: Functional polymorphisms in the base excision repair (BER) system were associated with increased 8-OHdG concentrations and thus with platinum sensitivity and prognosis in HG-SOCs.

Keywords
8-OHdG
Genetic polymorphism
Platinum sensitivity
High-grade serous ovarian carcinoma
Figures
Fig. 1.
Share
Back to top