IMR Press / EJGO / Volume 42 / Issue 2 / DOI: 10.31083/j.ejgo.2021.02.2248
Open Access Original Research
Expression and clinical relevance of cell division cycle associated 8 (CDCA8) gene in endometrial cancer patients
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1 Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 250012 Ji’nan, Shandong, China
2 Department of Obstetrics and Gynecology, The Affiliated Weihai Second Municipal Hospital of Qingdao University, 264200 Weihai, Shandong, China
Eur. J. Gynaecol. Oncol. 2021 , 42(2), 278–285; https://doi.org/10.31083/j.ejgo.2021.02.2248
Submitted: 17 September 2020 | Revised: 12 November 2020 | Accepted: 13 November 2020 | Published: 15 April 2021
Abstract

Objective: The cell division cycle associated 8 (CDCA8) gene is overexpressed in several cancers and has been associated with tumor progression. However, its expression and association with clinicopathological parameters and survival outcomes in patients with endometrial carcinoma (EC) remain obscure. Methods: We studied CDCA8 expression in EC patients utilizing data compiled by The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We examined CDCA8 expression concerning clinicopathological features and patient overall survival. Gene set enrichment analysis (GSEA) was performed to identify potential biological processes and signaling pathways involved. Results: CDCA8 was over-expressed in EC tumors compared to control tissues and was positively associated with worse tumor grade, FIGO stage, tumor (T) stage, nodal spread (N), and metastasis (M). High CDCA8 was associated with shorter overall survival but did not remain a significant independent predictor in multivariate analysis. Gene set enrichment analysis revealed important signaling pathways that may contribute to EC pathogenesis. Conclusion: CDCA8 was overexpressed in EC and positively correlated with poor clinicopathological features. CDCA8 warrants further investigation as a prognostic biomarker and therapeutic target in patients with EC.

Keywords
Endometrial cancer
Cell division cycle associated 8
Clinicopathological factors
Prognosis; Cancer biomarker
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