IMR Press / EJGO / Volume 42 / Issue 2 / DOI: 10.31083/j.ejgo.2021.02.2259
Open Access Original Research
Bilateral salpingo-oophorectomy in patients with uterine sarcoma: a multi-centre retrospective analysis
Show Less
1 Department of Obstetrics and Gynaecology, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
2 Department of Obstetrics and Gynaecology, Elisabeth TweeSteden Hospital, Doctor Deelenlaan 5, 5042 Tilburg, The Netherlands
3 Department of Education and Research, Catharina Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands
4 Department of Obstetrics and Gynaecology, Maxima Medical Centre, de Run 4600, 5504 DB Veldhoven, The Netherlands
5 Department of Pathology, Elisabeth TweeSteden Hospital, Doctor Deelenlaan 5, 5042 Tilburg, The Netherlands
Eur. J. Gynaecol. Oncol. 2021 , 42(2), 286–292; https://doi.org/10.31083/j.ejgo.2021.02.2259
Submitted: 27 September 2020 | Revised: 2 November 2020 | Accepted: 10 November 2020 | Published: 15 April 2021
Abstract

Objective: The aim of this study is to assess the effect of bilateral salpingo-oophorectomy (BSO) in patients with uterine sarcoma on recurrence rate and overall survival. Methods: Medical records of patients diagnosed with uterine sarcoma were reviewed. Survival rates and recurrence rates of patients with BSO and with ovarian preservation (OP) were calculated. Results: Fifty-one patients were included. Hysterectomy with BSO was performed in 21 patients (41%). Hysterectomy only, with OP was performed in 18 cases (35%). In 8 cases (17%) in addition to hysterectomy with BSO, a lymphadenectomy or debulking surgery was performed. The five-year overall survival rate (OS) for patients with OP was 78% and for patients with BSO only it was 52%. A Kaplan-Meier analysis showed a survival difference between patients with OP and patients with BSO, in favour of patients who had OP (log-rank P = 0.014). In the group of patients with FIGO stage 1&2, again a survival benefit was seen for patients who had OP (log-rank P = 0.020). The recurrence rate for patients with OP was 33% and 48% for patients with BSO (P = 0.366). The five-year OS for all patients with uterine sarcoma was 57% with a five-year recurrence of 33%. Conclusion: There is no significant decreased survival of patients who had OP surgery compared to patients who had BSO in case of uterine sarcoma. Primary ovarian sparing surgery can be considered for specific patients with uterine sarcoma.

Keywords
Uterine sarcoma
Treatment
Bilateral salpingo-oophorectomy
Survival
Recurrence
Figures
Fig. 1.
Share
Back to top