IMR Press / EJGO / Volume 42 / Issue 3 / DOI: 10.31083/j.ejgo.2021.03.2343
Open Access Original Research
Clinical characteristics and prognostic outcomes of gynaecological multiple primary malignant neoplasms
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1 Department of Gynaecology, the First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, Jiangsu, China
2 Department of Gynaecology, Nanjing Medical University, 210029 Nanjing, Jiangsu, China
Eur. J. Gynaecol. Oncol. 2021 , 42(3), 457–462; https://doi.org/10.31083/j.ejgo.2021.03.2343
Submitted: 8 December 2020 | Revised: 12 January 2021 | Accepted: 20 January 2021 | Published: 15 June 2021
Abstract

Objective: To investigate the clinical characteristics and the prognostic outcomes of patients with gynaecological multiple primary malignant neoplasms (MPMN). Materials and methods: For a period of ten years, from January 2008 to December 2018, patients with gynaecological MPMN were enrolled for this study. The clinical characteristics and survival outcomes were collected and analyzed. Results: A total of 126 patients with gynaecological MPMN were included, comprising 15 synchronous MPMN and 111 metachronous MPMN. The average age of the patients with gynaecological MPMN was 57.6 ± 10.8 years, and the probability of overall survival (OS) at 1, 2, 3, and 5 years was 88.6%, 82.6%, 76.9% and 68.7%, respectively. The OS of patients with gynaecological cancer as the first neoplasm was worse than those with non-gynaecological cancer as the first neoplasm (HR: 2.2, P = 0.049); the OS of patients accompanied by breast cancer was better than those accompanied by other cancers (HR: 0.346, P = 0.033). Univariate regression analysis showed that “age”, “FIGO stage” and “gynaecological cancer as the first neoplasm” were the factors for poor survival; “Accompanied by breast cancer” and “surgery for first or second neoplasm” were the factors for favourable survival. Conclusions: “Gynaecological cancer as the first neoplasm” is a factor for poor survival in patients with gynaecological MPMN, and “FIGO stage” is the independent risk factor (HR: 2.339, P = 0.001). “Accompanied by breast cancer” and “surgery for the neoplasm” are factors for favourable survival. Mostly, “surgery for the second neoplasm” was the independent protective factor (HR: 0.212, P = 0.005) for gynaecological MPMN.

Keywords
Gynaecological cancer
Multiple primary malignant neoplasms (MPMN)
Breast cancer
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