IMR Press / EJGO / Volume 42 / Issue 4 / DOI: 10.31083/j.ejgo4204119
Open Access Original Research

Association of the rs2430561 polymorphism of the interferon-𝜸 gene with cervical cancer susceptibility and prognosis in Han Chinese women

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1 Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China
2 Department of Breast Surgical Department, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China
3 Department of Second Gynecological Department, the Second Hospital of Dalian Medical University, 116000 Dalian, Liaoning, China

These authors contributed equally.

Eur. J. Gynaecol. Oncol. 2021 , 42(4), 788–794; https://doi.org/10.31083/j.ejgo4204119
Submitted: 25 November 2020 | Revised: 4 February 2021 | Accepted: 8 February 2021 | Published: 15 August 2021
Abstract

Objectives: To investigate IFN-γ rs2430561 polymorphisms in Han women in northeast China and the relationship between the rs2430561 polymorphisms and the risk of cervical cancer. Methods: PCR-ASP was used for genotyping. IFN-γ rs2430561 polymorphism was detected in 173 cases of cervical invasive carcinoma and 422 healthy controls in Han women in northeast China. Results: The allele and genotype distributions of the IFN-γ rs2430561 polymorphism were not significantly different between each of the groups (P > 0.05). There was no significant relationship between rs2430561 polymorphism and invasive cervical cancer (TT vs AA, OR = 1.321, 95% CI: 0.423–4.121, P = 0.632). The rs2430561 genotype was not associated with major clinicopathological features of invasive cervical cancer (P > 0.05). The polymorphism had no significant effect on overall survival (P = 0.071) or progression free survival (P = 0.067) of invasive cervical carcinoma. Conclusions: Rs2430561 polymorphism had no effect on invasive cervical cancer susceptibility in Han females in northeastern China, and was not associated with the prognosis of invasive cervical carcinoma.

Keywords
Cervical cancer
Single nucleotide polymorphism
Genetic susceptibility
IFN-γ
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