IMR Press / EJGO / Volume 42 / Issue 4 / DOI: 10.31083/j.ejgo4204120
Open Access Original Research
Analysis and comparison of the prevalence and genotype distribution of human papillomavirus in two different areas of China: a cross-sectional study
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1 Department of Obstetrics and Gynecology, Peking University People’s Hospital, 100044 Beijing, China
2 Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, 610041 Chengdu, Sichuan, China
3 Department of Gynecology, Affiliated Hospital of Inner Mongolia University for the Nationalities, 028007 Tongliao, The Inner Mongolia Autonomous Region, China
4 Department of Obstetrics and Gynecology, Huidong County People’s Hospital, 615200 Liangshan Yi Autonomous Prefecture, Sichuan, China
Eur. J. Gynaecol. Oncol. 2021 , 42(4), 795–801; https://doi.org/10.31083/j.ejgo4204120
Submitted: 9 December 2020 | Revised: 2 February 2021 | Accepted: 5 February 2021 | Published: 15 August 2021
Abstract

Objectives: This study investigated and compared the prevalence and distribution of high-risk human papillomavirus (HR-HPV) genotypes in Tongliao and Huidong regions of China. Materials and methods: A cross-sectional study of the results of cervical cancer screening was conducted between August 2017 and April 2018 in Tongliao, Inner Mongolia as well as Huidong, Sichuan Province, China. Totals of 2351 and 1583 women recruited in Tongliao and Huidong, respectively, who underwent cytology sampling, collected for thinprep cytologic tests (TCT) and PCR-based HPV genotyping tests. Participants whose HPV and TCT results met relevant indications were referred for colposcopy. Results: The overall prevalence in the Tongliao and Huidong cohorts were 19.35% and 10.4% (P < 0.05), among which the five most common genotypes were HPV16 (3.91%), 52 (3.79%), 53 (2.42%), 68 (2.04%), and 51 (1.96%) in Tongliao and HPV52 (2.27%), 16 (1.58%), 58 (1.39%), 51 (1.39%), and 53 (0.95%) in Huidong. In both cohorts, single-type infections were more common than multiple-type infections. HPV16 was the most common genotype in high-grade squamous intraepithelial lesions. In the Tongliao cohort, HPV33, HPV52, and HPV58 showed a risk of carcinogenesis similar to HPV18. Conclusions: This study provides information on HPV prevalence and genotype distribution in Tongliao and Huidong. The HPV prevalence and genotype distribution were found to differ geographically. The HPV genotyping tests provided more details, which can be instructive and meaningful for both the prevention and management of HPV infection and cervical lesions.

Keywords
Human papillomavirus
Prevalence
Genotypes
Cervical cancer
Cervical intraepithelial neoplasia
Figures
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