IMR Press / EJGO / Volume 42 / Issue 5 / DOI: 10.31083/j.ejgo4205132
Open Access Original Research
Cervical cone dimension and linear CIN extension trend: 28 years’ experience of a tertiary center
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1 Department of Surgical Sciences, Gynecology and Obstetrics 1, City of Health and Science, University of Torino, 10126 Torino, Italy
Eur. J. Gynaecol. Oncol. 2021 , 42(5), 865–870;
Submitted: 7 May 2021 | Revised: 6 July 2021 | Accepted: 20 July 2021 | Published: 15 October 2021

Objective: To evaluate trend in cervical cone length and CIN linear extension in women treated in a tertiary referral centre over a 28 years period. Methods: A retrospective study including 3716 women treated with cervical conization for biopsy-proven HSIL (CIN grade 2 and 3), glandular lesions and microinvasive squamous cervical cancer from 1992 to 2020. Relevant clinical and histopathological data were collected. Results: A mean cone length of 9.5 mm (SD 5.1 mm, range 1–40 mm) and CIN linear extension of 6.58 mm (SD 3.38 mm, range 1–45 mm) were found. A 35% significant decrease in cone length was observed in the 28 years period, while no differences were found in CIN extension. Furthermore, ectocervical and endocervical margin positivity rates were stable over the study period and not affected by decreasing cone length. Conclusion: The current study reported a significant trend of reduction in cone length from 1992 to 2020 while margin status was unaffected. This may reflect less invasive approach and increased attention to obstetric outcomes.

Cervical intraepithelial neoplasia
Cervical conization
Cone dimension
Linear CIN extension
Fig. 1.
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