IMR Press / EJGO / Volume 43 / Issue 1 / DOI: 10.31083/j.ejgo4301002
Open Access Case Report
Multi-modality therapies for advanced small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): three case reports and literature review
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1 Department of Obstetrics and Gynecology, The Third Hospital of Peking University, 100191 Beijing, China

Academic Editor: Enrique Hernandez

Eur. J. Gynaecol. Oncol. 2022 , 43(1), 2; https://doi.org/10.31083/j.ejgo4301002
Submitted: 22 September 2021 | Revised: 27 October 2021 | Accepted: 1 November 2021 | Published: 12 January 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but highly undifferentiated, aggressive malignancy that primarily affects young women. Most SCCOHT patients present with advanced disease and have a very poor prognosis. Although several therapeutic regimens have been proposed, there is no consensus on the optimal treatment strategy. Case: Herein, we describe three cases of advanced-stage SCCOHT aged from16 to 36 treated with cytoreductive surgery and chemotherapy with or without immune checkpoint blockade treatment. With different strategy, the patients showed utterly different outcomes. Conclusion: The cases highlight the importance of prompt diagnosis as well as early, aggressive, and combined modality treatment of SCCOHT. We believe that improved therapies could result in more young patients surviving SCCOHT.

Keywords
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT)
Advanced stage
Tumor immunotargeted therapy
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