IMR Press / FBE / Volume 13 / Issue 2 / DOI: 10.52586/E880
Open Access Article
Genetic predisposition of TNFα gene polymorphism in South-Indian Migraineurs and meta-analysis
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1 Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), 603103 Kelambakkam, Tamilnadu, India
2 Department of Neurology, Chettinad Super Speciality Hospital, Chettinad Health City, 603103 Kelambakkam, Tamil Nadu, India
3 Drug Discovery and Multi-omics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE), 603103 Kelambakkam, Tamilnadu, India

These authors contributed equally.

Front. Biosci. (Elite Ed) 2021 , 13(2), 226–236; https://doi.org/10.52586/E880
Submitted: 28 April 2021 | Revised: 2 August 2021 | Accepted: 10 August 2021 | Published: 20 December 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract

Migraine (Mg) is a multifaceted neurovascular disorder caused by genetic and several environmental etiologies. We have implemented a case-control study of TNFα gene polymorphism in 212 Mg patients and 218 healthy controls utilizing the ARMS-PCR technique, followed by Sanger sequencing. Besides, we have conducted a meta-analysis of different genetic models (five genetic models) to combine and summarize the available data from 11 studies (including this present research). The strength of genetic associations in the meta-analysis used to assess by the pooled odds ratio (OR) and 95% confidence intervals (CI). The results of this case-control study discovered a significant relationship with Mg in recessive and homozygous genotype with OR = 2.35 (95% CI [0.96–5.74]), p-value = 0.045. Also, the outcomes of meta-analysis suggested an irrelevant relationship between TNFα gene (rs1800629) polymorphism and Mg susceptibility in the five genetic models. However, subgrouping based on ethnic background showed a significant association in the allelic genetic model with OR = 1.53 (95% CI [1.02–2.31]), p = 0.040 respectively. The meta-analysis results of TNFα gene polymorphism may represent a risk factor for Mg among Asians. In the future, large scale, multicentric case-control study by classification of patients with Mg with or without aura can be performed worldwide to identify the potential genetic risk factors leading to Mg pathogenesis.

Keywords
Mg
TNFα
Association
rs1800629
Meta-analysis
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