Academic Editor: Marcello Iriti
Purpose: Cisplatin (CIS) is a platinum based anticancer drug that has
demonstrated significant efficacy against various types of cancers.
Unfortunately, this drug is also famous for its severe side effects on delicate
organs. Herein this study examined the hepatorenal and testicular protective
effects of TiTE against CIS-induced hepatorenal and testicular insults.
Methods: Rats were administered with TiTE (250 and 500 mg/kg body
weight) for 4 weeks, while a single dose of CIS (2.5 mg/kg body weight) was
injected once per week from week 2 to week 4. Results: Treatment with
TITE significantly attenuated CIS-induced increases in serum creatinine, blood
urea nitrogen (BUN), uric acid, alanine aminotransferase (ALT) and aspartate
aminotransferase (AST). Furthermore, TiTE treatment also decreased oxidative
stress (MDA) inflammations (TNF-