IMR Press / JIN / Volume 21 / Issue 1 / DOI: 10.31083/j.jin2101003
Open Access Original Research
Impact of subjective dizziness on motor and non-motor symptoms in patients with early stages of Parkinson's disease
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1 Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, 04401 Seoul, Republic of Korea
2 Department of Biostatistics and Data Innovation, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, 04401 Seoul, Republic of Korea
*Correspondence: denovo78@naver.com (Kyum-Yil Kwon)
J. Integr. Neurosci. 2022, 21(1), 3; https://doi.org/10.31083/j.jin2101003
Submitted: 15 August 2021 | Revised: 15 October 2021 | Accepted: 31 October 2021 | Published: 20 January 2022
(This article belongs to the Special Issue Parkinson's disease)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Clinicians sometimes encounter patients with Parkinson’s disease complaining of dizziness in real clinical settings. We sought to identify the relationship between self-perceived dizziness and motor or non-motor symptoms, especially in Parkinsonian patients in the early stages. Eight-six patients with less than five years of Parkinson’s disease duration were recruited. We used the dizziness handicap inventory to access self-reported dizziness in patients with early Parkinson’s disease. Parkinsonian motor symptoms such as postural instability and gait difficulty and non-motor features for global cognitive function, depressive mood, anxiety state, fatigue state, and autonomic dysfunction were measured using representative scales. Linear regression analysis demonstrated that the dizziness handicap inventory score was significantly related to postural instability and gait difficulty, anxiety, gastrointestinal, and cardiovascular domain of dysautonomia. In addition, the dizziness handicap inventory score was positively correlated with scores for postural instability and gait difficulty, anxiety, gastrointestinal, and cardiovascular dysautonomia. We found that self-reported dizziness was highly linked to postural instability and gait difficulty, anxiety, gastrointestinal and cardiovascular dysfunctions in patients with early Parkinson’s disease. Further follow-up studies on the association between dizziness and the pathophysiology of Parkinson’s disease are needed.

Keywords
Dizziness
Dysatonomia
Motor
Non-motor
Parkinson's disease
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