Background: Biomarker detection strategies have, in recent years, been
moving towards nucleic acid-based detection systems in the form of aptamers,
short oligonucleotide sequences which have shown promise in pre-clinical and
research settings. One such aptamer is M5-15, a DNA aptamer raised against human
alpha synuclein (
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Development and validation of anti-human Alpha synuclein DNA aptamer using computer modelling techniques—an in silico study
Marcus Rock1, Georgios D. Zouganelis1,*, Ana Flavia Belchior de Andrade1, Samantha J. Drake1, Athanasios Alexiou2,3, Ashraf Albrakati4, Gaber El-Saber Batiha5, Thomas Arron Illingworth1
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1
Human Sciences Research Centre, University of Derby, DE22 1GB Derby, UK
2
Department of Science & Engineering, Novel Global Community Educational Foundation, 2770 Hebersham, Australia
3
AFNP Med Austria, 1010 Wien, Austria
4
Department of Human Anatomy, College of Medicine, Taif University, P.O. BOX 11099, 21944 Taif, Saudi Arabia
5
Department of Pharmacology & Therapeutics, Faculty of Veterinary Medicine, Damanhour University, 22511 Damanhour, AlBeheira, Egypt
*Correspondence: g.zouganelis@derby.ac.uk (Georgios D. Zouganelis)
J. Integr. Neurosci. 2022, 21(1), 5;
https://doi.org/10.31083/j.jin2101005
Submitted: 1 August 2021 | Revised: 26 August 2021 | Accepted: 18 September 2021 | Published: 21 January 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
DNA aptamers
In silico design
Computer aided design
Alpha synuclein
Biomarker detection
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