There occurs a progressive weakness and wastage of skeletal muscle in different
types of muscular dystrophy. The loss of muscle fibers in dystrophic muscle with
impaired function is associated with leakage of intracellular enzymes,
maldistribution of electrolyte content and metabolic defects in myocytes. Marked
increases in the sarcolemma (SL) Na
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Role of molecular and metabolic defects in impaired performance of dystrophic skeletal muscles
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1
Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre and Department of Physiology and Pathophysiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R2H 2A6, Canada
2
School of Medicine, Jordan University of Science and Technology, Irbid, 3030 Ar-Ramtha, Jordan
3
Department of Kinesiology, Nutrition and Food Science, California State University, Los Angeles, CA 90802, USA
*Correspondence: nsdhalla@sbrc.ca (Naranjan S. Dhalla)
J. Mol. Clin. Med. 2021, 4(2), 47–67;
https://doi.org/10.31083/j.jmcm0402005
Submitted: 4 November 2020 | Revised: 8 May 2021 | Accepted: 26 May 2021 | Published: 20 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Dystrophic muscle
Dystrophin deficiency
Sarcolemmal defects
Sarcoplasmic reticular Ca2+-handling
Store-operated Ca2+-channels
Mitochondrial Ca2+-overload
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Fig. 1.