IMR Press / RCM / Volume 12 / Issue 2 / DOI: 10.3909/ricm0562

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Immunology Insights Into Cardiac Allograft Rejection
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1 Cardiovascular and Thoracic Department, Policlinico G. Martino University Hospital, University of Messina, Italy
Rev. Cardiovasc. Med. 2011, 12(2), 68–76; https://doi.org/10.3909/ricm0562
Published: 30 June 2011
Abstract
Despite long-term complications from chronic immunosuppressive therapy, the phenomenon of chronic rejection is still a limitation in cardiac allograft recipients. In this review, starting from basic immunologic concepts, we analyze the mechanisms involved in rejection following heart transplantation, with particular emphasis on chronic rejection manifested as cardiac allograft vasculopathy (CAV). Etiopathogenesis of CAV and diagnostic imaging studies are also discussed.
Keywords
Immunology
Heart transplantation
Surgery
Complications
Rejection
Coronary artery pathology
Pharmacology
Physiology
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