IMR Press / RCM / Volume 18 / Issue 4 / DOI: 10.3909/ricm0889
Open Access Review
Hyperuricemia and Cardiovascular Disease
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1 Cardiology Unit, Department of Internal Medicine, University of Siena, Italy
2 Baylor University Medical Center, Dallas, TX
3 Southern Methodist University, Dallas, TX
4 Baylor Heart and Vascular Hospital, Dallas, TX
5 Baylor Heart and Vascular Institute, Dallas, TX
Rev. Cardiovasc. Med. 2017 , 18(4), 134–145; https://doi.org/10.3909/ricm0889
Abstract
Uric acid (UA), the metabolic mediator of gout and urate renal stones, is associated with increased cardiovascular risk burden. Hyperuricemia is a common metabolic disorder, and interaction among UA and cardiovascular diseases has been clearly described. Several illnesses, including hypertension, myocardial infarction, metabolic syndrome, and heart failure, are related to increases in UA levels. In this article, we discuss the pathophysiology of hyperuricemia and describe the biologic plausibility of this metabolite's participation in the pathogenesis of cardiovascular illness. We conclude by discussing the implications of lowering plasma UA concentrations to reduce the risk of cardiovascular events, including myocardial infarction, stroke, heart failure, and cardiovascular death.
Keywords
Hyperuricemia
Uric acid
Inflammation
Cardiovascular disease
Risk
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