Potential roles of microRNA-1 and microRNA-133 in cardiovascular disease

² Cardiovascular Medicine Department, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, P. R. China

³ Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, P. R. China

⁴ Shandong Provincial Sino-US Cooperation Research Center for Translational Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, P. R. China

⁵ The Center for Molecular Genetics of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, P. R. China

^*Correspondence: yanbo@mail.jnmc.edu.cn (Bo Yan)

Rev. Cardiovasc. Med. 2020, 21(1), 57–64; https://doi.org/10.31083/j.rcm.2020.01.577

Submitted: 15 October 2019 | Accepted: 14 February 2020 | Published: 30 March 2020

This is an open access article under the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/.

Abstract

Cardiovascular disease is still the main cause of morbidity and mortality worldwide. Currently, the frontier of research into cardiovascular disease is the field of non-coding RNA. In this review, information was collected on the use of micro-RNAs as non-invasive biomarkers and their role in pathophysiological processes and therapeutic applications. In the case of microRNA-1 and microRNA-133, the roles and regulatory mechanisms of them are reviewed for arrhythmia, myocardial infarction, diabetic cardiomyopathy, myocardial hypertrophy, cardiomyocyte differentiation, and cell reprogramming. It was observed that microRNA-1 and microRNA-133 do not exist independently, but are two co-transcriptional and cooperative regulatory factors. They have diagnostic value as biomarkers, but also have the potential as therapeutic targets such as for antiarrhythmia and cardiac reprogramming.

Keywords

Micro-RNA

differentiation

myocardial hypertrophy

arrhythmia

reprogramming

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