† These authors contributed equally.
Academic Editor: Ichiro Wakabayashi
Metabolic Syndrome (MS) remains the leading cause of mortality and morbidity
globally. Adipose tissue releases adipokines that play key roles in metabolic and
cardio-cerebro-vascular homeostasis. Subfatin, induced after exercise or upon
cold exposure in adipose tissue, is a novel secreted protein homologous to Metrn,
a neutrophic factor with angiogenic properties. The protein was proved to be of
great significance in the browning of white adipose tissue (BWT) and insulin
resistance (IR). It affected insulin sensitivity at least via its local
autocrine/paracrine action through AMP-activated protein kinase (AMPK) or
peroxisome proliferator-activated receptor