Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China

Na Ta^1,†, Mengwei Liu^1,†, Yue Wang¹, Fanxin Zeng¹, Fangfang Nie¹, Mengke Shang¹, Xiaotong Wang¹, Yuetian Yang¹, Man Liang¹, Lu Wen¹, Lanxin Ou¹, Zhibin Yang¹, Wanyang Liu^1,*, Xiuping Liu^1,2,*

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¹ Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, 110122 Shenyang, Liaoning, China

² Department of Nursing, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China

^*Correspondence: wyliu@cmu.edu.cn (Wanyang Liu); liuxp@sj-hospital.org (Xiuping Liu)
^† These authors contributed equally.
Academic Editor: Takatoshi Kasai

Rev. Cardiovasc. Med. 2021, 22(3), 895–901; https://doi.org/10.31083/j.rcm2203096

Submitted: 8 April 2021 | Revised: 2 June 2021 | Accepted: 21 June 2021 | Published: 24 September 2021

(This article belongs to the Special Issue State-of-the-Art Cardiovascular Medicine in Asia 2021)

This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).

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Abstract

Hypertension is a complex disease which is mainly influenced by genetic factors. Recently, genome-wide association study (GWAS) found three novel endothelial dysfunction-related sites: Vascular endothelial growth factor A (VEGFA) rs9472135, Faciogenital dysplasia 5 (FGD5) rs11128722, Zinc Finger C3HC-type Containing 1 (ZC3HC1) rs11556924. Endothelial dysfunction is one of the early events in pathophysiology of essential hypertension. To investigate the association of endothelial dysfunction-related genes with essential hypertension, we conducted a case-control study of 431 patients with hypertension and 345 controls. The polymorphisms were detected using Taqman Probe. The alleles and genotypes of ZC3HC1 rs11556924 and VEGFA rs9472135 were not statistically different between the two groups, while the allele of FGD5 rs11128722 was different [P = 0.045, OR = 1.265, 95% CI = (1.009–1.586)], especially in the male [P = 0.035, OR = 1.496, 95% CI = (1.037–2.158)]. Analyzing the different of genotype distribution of 3 SNPs in the two groups under different genetic models, the genotypes of FGD5 rs11128722 showed difference in male under dominant model [P = 0.049, OR = 1.610, 95% CI = (1.018–2.544)]. The polymorphism of FGD5 rs11128722 had a significant difference in Body Mass Index (BMI) among different genotypes; In the additive genetic model, BMI of GA genotype was higher than that of GG (P = 0.038); GA + AA was higher than GG in the dominant genetic model (P = 0.011). In our study, we found that the polymorphisms of VEGFA rs9472135 and ZC3HC1 rs11556924 may not significantly associated with the risk of essential hypertension, and FGD5 rs11128722 may increase the risk of it, especially in elderly men.

Keywords

Essential hypertension

Polymorphism

Vascular endothelial dysfunction

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