Academic Editor: Matina Kouvari
Central obesity is associated with increased level and activity of endothelin-1.
The waist and hip circumferences are simple indicators of central obesity. Waist
circumference correlates with visceral adiposity, whereas hip circumference
associates with gluteofemoral peripheral adiposity. Both measurements have
independent and opposite correlation with coronary artery disease (CAD) risk
factors. The relation between serum endothelin-1 in stable CAD and both
parameters of central obesityneeds to be investigated. This study aims to examine
the correlation between serum endothelin-1 level and waist and hip circumferences
as parameters of central obesity in patients with stable CAD. This was a
cross-sectional study. Consecutive subjects were enrolled among those who
underwent elective coronary angiography with significant CAD. Serum endothelin-1
was measured from peripheral blood samples taken before coronary angiography
procedure. The measurement of waist circumference, hip circumference, and ratio
derived from them, was performed. Central obesity was determined by waist
circumference cut-off for Indonesian population. The correlation analysis was
performed with Pearson test. The multivariate analysis was performed with
multiple linear regression test. The comparison of serum endothelin-1 level
between groups was performed with Student T test. We enrolled 50
subjects. The majority of subjects was male (80.0%), hypertensive (86.0%),
dyslipidemic (68%) and smoker (52%). Most subjects had history of acute
coronary syndrome (64%). Mean waist circumference was 87.6 +/– SD cm, hip
circumference was 95.3 cm +/– SD, mean waist-to-hip ratio was 0.92 +/– SD and
mean waist-to-height ratio was 0.54 +/– SD. Central obesity occurred in 32% of
subjects. Mean serum endothelin-1 level was 2.2