† These authors contributed equally.
Academic Editor: Peter A. McCullough
Limited data suggests possible gender-specific association between serum uric
acid (SUA) and cardiovascular disease (CVD) incidence. The aim of the present
analysis was to evaluate the association between SUA levels and 10-year CVD
incidence (2002–2012) in the ATTICA study
participants. Overall, 1687 apparently healthy volunteers, with SUA
measurements, residing in the greater metropolitan Athens area (Greece), were
included. Multivariable Cox-regression models were used to estimate the hazard
ratios for SUA in relation to 10-year CVD incidence. Receiver operating curve
analysis was conducted to detect optimal SUA cut-off values. Participants in the
2nd and 3rd SUA tertile had 29 and 73% higher 10-year CVD incidence compared
with those in the 1st tertile (p