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The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction
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1
Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, 100029 Beijing, China
2
Department of Ultrasound, The Third Medical Center of PLA General Hospital, 100039 Beijing, China
*Correspondence: wesleymu@hotmail.com (Junsheng Mu); zhoufan29@sina.com (Fan Zhou)
Academic Editor: Calogera Pisano
Academic Editor: Calogera Pisano
Rev. Cardiovasc. Med. 2021, 22(4), 1167–1171;
https://doi.org/10.31083/j.rcm2204125
Submitted: 28 June 2021 | Revised: 12 August 2021 | Accepted: 1 September 2021 | Published: 22 December 2021
(This article belongs to the Special Issue New Frontiers in Cardiac Surgery: Biomarkers and Treatment)
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Ischemic heart disease resulting from a myocardial infarction (MI), is a major health issue. Stem cell therapies may play an important role in this field. However, cardiomyocytes induced from stem cells are characterized by low rates of differentiation and immaturity. After transplantation into the damaged heart, they may even increase the risk of arrhythmias. Studies have demonstrated that electrical stimulation (ES) can promote the cardiac differentiation of stem cells. This review summarizes the latest research on the effects of applying different electrical stimulation (ES) parameters to different types of stem cells and the related mechanisms that may be involved.
Keywords
Electrical stimulation
Stem cells
Myocardial infarction
Cardiac differentiation