IMR Press / RCM / Volume 23 / Issue 1 / DOI: 10.31083/j.rcm2301014
Open Access Review
Sex differences in ventricular arrhythmia: epidemiology, pathophysiology and catheter ablation
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1 Electrophysiology and Ablation Unit and LIRYC, 33600 CHU de Bordeaux, France

Academic Editors: Bernard Belhassen and Petr Ostadal

Rev. Cardiovasc. Med. 2022 , 23(1), 1;
Submitted: 13 September 2021 | Revised: 2 November 2021 | Accepted: 10 November 2021 | Published: 14 January 2022
(This article belongs to the Special Issue Catheter Ablation of Ventricular Tachycardia)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Evidence on sex differences in the pathophysiology and interventional treatment of ventricular arrhythmia in ischemic (ICM) or non-ischemic cardiomyopathies (NICM) is limited. However, women have different etiologies and types of structural heart disease due to sex differences in genetics, proteomics and sex hormones. These differences may influence ventricular electrophysiological parameters and may require different treatment strategies. Considering that women were consistently under-represented in all randomized-controlled trials on VT ablation, the applicability of the study results to female patients is not known. In this article, we review the current knowledge and gaps in evidence about sex differences in the epidemiology, pathophysiology and catheter ablation in patients with ventricular arrhythmias.

Ventricular arrhythmia
Ventricular tachycardia
Catheter ablation
Sex difference
Fig. 1.
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