Heart failure pathogenesis and management: heart failure with preserved ejection fraction

Dear Colleagues,

HFpEF is a complex clinical syndrome in which heart is unable to deliver adequate oxygen to the tissues required by the metabolic needs or delivers it at the expense of increased filling pressures despite a normal Ejection Fraction. Multiple comorbid conditions such as diabetes, atrial fibrillation, uncontrolled hypertension, multivessel coronary disease not amenable for intervention, morbid obesity, COPD, pulmonary hypertension, Chronic kidney disease and right heart failure are all contributing to the worsening of HFpEF. No specific treatment in clinical trials has shown to be beneficial in improving outcomes. Hence there is an urgent need to discuss the knowledge gained so far in pathophysiology, biomarkers, comorbidity management, newer therapies in diabetes management, exercise physiology and potential benefits as well as potential newer device therapies and use of technology to improve outcomes. 

Goal of this issue: 

To summarize the current knowledge in epidemiology, pathogenesis, newer biomarkers of interest in cardiorenal space, differential diagnosis and co management of concurrent conditions, discussion of current knowledge on clinical trials, role of exercise and rehab, and translate evidence from subgroups to gain newer hypothesis in innovative therapies for the future. In addition, in this era of advanced technology, there is an opportunity to discuss utilization of AI, remote technology, and Internet of Things to assess potential benefit in development of newer treatment strategies.

Prof. Dr. Krishnaswami Vijayaraghavan

Guest Editor

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