IMR Press / EJGO / Volume 38 / Issue 3 / DOI: 10.12892/ejgo3436.2017
Open Access Original Research
A preliminary study for the treatment of cervical colposcopic lesions with the biological compound AV2
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1 Hospital de la Familia, Juarez, Mexico
2 University of Kinshasa, Department of Obstetrics and Gynecology, Kinshasa, Democratic Republic of the Congo
3 University of Antwerp, International Health Unit, Antwerp, Belgium
4 University of Antwerp, Department of Obstetrics and Gynecology, Antwerp, Belgium
Eur. J. Gynaecol. Oncol. 2017 , 38(3), 342–345; https://doi.org/10.12892/ejgo3436.2017
Published: 10 June 2017
Abstract

Objective: To evaluate the efficacy of AntiViral 2 (AV2) in the regression of moderate and severe colposcopic lesions, when compared to placebo. Materials and Methods: Women, aged over 18 years with a colposcopic diagnosis of moderate to severe dysplasia were randomized to receive either two applications of AV2 or placebo within four days. Both examining physician and patients were blinded to the treatment option. Follow-up colposcopy was performed on days 11, 21, and 60. Results: A total of 50 patients were enrolled in this study. There was no statistically significant difference in screening entry criteria between the two groups. The results showed that the application of AV2 yielded a reduction of more than 50% for 21 out of 28 (75%) patients who received the active treatment versus a 0% for the comparable placebo group (p < 0.001). Conclusions: The authors conclude that AV2 can have a place in the treatment of colposcopically-detected cervical lesions. Due to the proven broad spectrum antiviral activity of AV2, a plausible explanation is that the lesions regress due to deactivation of the virus. Further trials with larger numbers and detailed cytology and histology are needed to confirm these results.
Keywords
Cervical lesion
Colposcopy
Human papillomavirus
AV2
Essential oil
Treatment
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