IMR Press / EJGO / Volume 39 / Issue 1 / DOI: 10.12892/ejgo3882.2018
Open Access Original Research
Are colposcopy and electrical impedance spectroscopy complementary when used to detect high-grade cervical neoplasia?
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1 Colposcopy Clinic, Jessop Wing, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
2 Medical Physics, University of Sheffield, Sheffield, United Kingdom
3 Medical Physics, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
Eur. J. Gynaecol. Oncol. 2018 , 39(1), 70–75; https://doi.org/10.12892/ejgo3882.2018
Published: 10 February 2018
Abstract

Purpose of investigation: To evaluate if colposcopy and electrical impedance spectroscopy (EIS) are complementary and hence increase the detection of high-grade cervical intraepithelial neoplasia (HG-CIN). Materials and Methods: A cohort of 1,237 women with an abnormal cervical cytology result referred to a single colposcopy service to assess the value of EIS as an adjunct to colposcopy for the detection of HG-CIN. Results: Fifty-three (12.8%) extra cases of HG-CIN were detected by a combination of colposcopy and EIS (466 vs. 413). Ten cases were referred with high-grade cytology and 43 were associated with low-grade cytology. The increased detection of HG-CIN in women referred with low-grade cytology was 50% (129 vs. 86). The combination of colposcopy and EIS produced a highly significant improvement in the detection of HG-CIN. Conclusions: Comparison of the performance metrics with a previous multi-centre trial shows that use of EIS as an adjunct increases performance over that obtained from colposcopy alone. The largest improvement is in increased sensitivity and NPV when used to detect HG-CIN, particularly in women referred with low-grade cytology.
Keywords
Cervical smear
Colposcopy
Cervical intraepithelial neoplasia
Electrical impedance spectroscopy
Treatment
Loop electrosurgical excision procedure
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