IMR Press / EJGO / Volume 40 / Issue 1 / DOI: 10.12892/ejgo4629.2019
Open Access Case Report
Ovarian clear cell carcinoma associated with endometriosis: a case report and literature review
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1 Department of Medicine, Nazarbayev University School of Medicine, Astana, Kazakhstan
2 Department of Gynecology, National Research Center of Mother and Child Health, University Medical Center, Astana, Kazakhstan
3 Clinic of Obstetrics and Gynecology, Clinical Centre of Serbia, Belgrade, Serbia
4 Medical Faculty, University of Belgrade, Belgrade, Serbia
5 Department of Cellular Pathology, PathLinks Pathology Services, Lincoln County Hospital, Lincoln, United Kingdom
6 Department of Obstetrics and Gynecology “Filippo Del Ponte” Hospital, University of Insubria, Varese, Italy
Eur. J. Gynaecol. Oncol. 2019 , 40(1), 166–169;
Published: 10 February 2019

Purpose: The purpose of this report was to confirm that endometriosis, although a benign gynecological disease, in some patients, can give rise to ovarian cancers. Case Report: The authors report a case of clear cell carcinoma in a patient suffering of endometriosis. The patient, a 38-year old nullipara, had a history of bilateral ovarian cysts diagnosed on routine check-up by ultrasound scan four years ago. After admission to hospital, due to cramping lower abdominal pain, MRI showed tumorous mass, with solid and cystic components, located between abdominal wall, lateral pelvic walls, and lumbosacral part of spine belonging to ovaries. The patient underwent appropriate extensive surgery. Histopathological investigation revealed ovarian clear cell adenocarcinoma Stage IIIa, along with endometriotic cyst found on the contralateral side. Conclusion: This report confirms the strong link between endometriosis and ovarian cancer and sends an appeal for urgent and precise definition of parameters relevant for determination of patients’ groups with the risk for malignancy.

Clear cell carcinoma
Ovarian tumor
Figure 1.
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